VirtualBox issues in Mac OSX 10.13.4

[BrokenMouse]

We are see unusual behavior in VirtualBox in our environments. Currently users who have VirtualBox 5.2.8 installed on a Mac OSX machine pre 10.13.4 and then upgrade, we are seeing this error when they try to open the application:

aRC=E_ACCESSDENIED (0x80070005) aIID={9570b9d5-f1a1-448a-10c5-e12f5285adad} aComponent={VirtualBoxWrap} aText={The object is not ready}, preserve=false aResultDetail=0

If we install the same VirtualBox on a machine that received the update during a fresh install, VirtualBox starts and works just fine.

Steps taken:
1) Clean removals and installs of VirtualBox
2) Making sure the appropriate kext are running
2a) Making sure no KEXT is running under VirtualBox after a the uninstall
3) Making sure our management software has the correct white listing for Oracle and VirtualBox
4) Removed and cleaned all other Virtualization and container products

Reproduction:
Update MacOSx to 10.13.4 from a previous version
Install VirtualBox
Open
Error

Success:
-Install VirtualBox on a machine after a clean install
Works

[Klaus Espenlaub]

In the logs you provided I can't spot a real problem - the issue (from your symptom description) seems that the VM manager UI terminates prematurely, and the API then terminates due to lack of clients after the usual 5 second timeout. Can't tell what causes the UI confusion.