Of course we care, but several people seem to take those warnings far too seriously.
VirtualBox does not (and never did) any kind of re-buffering of read/write requests issued by the guest to guarantee alignment. This means that if the guest does unaligned reads/writes (and this can happens especially during initial bootstrap) such warnings are unavoidable.
It is only something to worry about if those warnings happen extremely frequently and during normal guest OS operation.
This can actually also happen generally with certain disk image formats (e.g. very old VDI images only used 512 byte alignment, more recent ones use 4K alignment and soon this will be increased again, and due to some allocation quirks VMDK can only achieve 2K alignment).