id summary reporter owner description type status component version resolution keywords cc guest host 20627 Failed to load R0 module C:\Program Files\Oracle\VirtualBox/VMMR0.r0: SUP_IOCTL_LDR_OPEN failed (VERR_LDR_GENERAL_FAILURE). ap31415 "On a Windows 10 Pro host with build 19043.1288, I installed VirtualBox-6.1.28-147628-Win.exe. Trying to run any VM results in the error: Failed to load R0 module C:\Program Files\Oracle\VirtualBox/VMMR0.r0: SUP_IOCTL_LDR_OPEN failed (VERR_LDR_GENERAL_FAILURE). Reverting to VirtualBox-6.1.26-145957-Win.exe, everything works fine." defect closed other VirtualBox 6.1.28 fixed other Windows