id summary reporter owner description type status component version resolution keywords cc guest host 18048 """SUPLIB not initiated successfully"" with --disable-hardening --build-debug ==> fixed in SVN" Cake "In VirtualBox-5.2.18/src/VBox/VMM/VMMR3/VM.cpp * Line 212 calls VMR3GlobalInit, which eventually ends up calling suplibOsIOCtl. * Line 238 calls SUPR3Init, which is too late. The VM starts when I call SUPR3Init(NULL) earlier. I attached a patch, but I assume you will know how to fix it better. I see someone else has experienced this issue before: https://forums.virtualbox.org/viewtopic.php?f=10&t=84300" defect closed VMM VirtualBox 5.2.18 fixed Windows Linux