id,summary,reporter,owner,description,type,status,component,version,resolution,keywords,cc,guest,host 12601,4.3.6 Cannot access the kernel driver,A_User_Called_M,,"Host: Windows Vista Home Premium 32 bit SP2 Intel Core 2 Cpu 6600 Upgrading from 4.2.18 (or 4.2.16) Installed 4.3.6, and getting this error. Failed to open a session for the virtual machine fed13. The virtual machine 'fed13' has terminated unexpectedly during startup with exit code 1. Result Code: E_FAIL (0x80004005) Component: Machine Interface: IMachine {480cf695-2d8d-4256-9c7c-cce4184fa048} ----------- I then: - rebooted - uninstalled virtualbox. Removed all files from programfiles and from config. [1] - rebooted - run the installer as admin (anti virus (avg) and firewall disabled) - rebooted I have UAC turned off. (But trying with it turned on made no difference) [1] According to autoruns from SysInternals, there where a few Vbox.... files in system32/drivers that where registered as part of ""Sun Virtualbox"" (very old). I removed them too. Still get the error. (With a newly created guest (fedora) I have a log of the MSI install. ",defect,closed,other,VirtualBox 4.3.6,obsolete,,,other,Windows